McGill researchers get $34M in CIHR Project Grant funding

January 30, 2020  —  Uncategorized

The Canadian Institutes for Health Research (CIHR) has awarded more than $34 million in funding to numerous researchers at McGill and its affiliated hospitals and institutes through the Fall 2019 Project Grant competition.

CIHR awarded 385 health research projects across the country totalling approximately $275 million. Fifty-one of the projects awarded research grants are led by McGill researchers.

“I would like to congratulate the researchers and their teams of trainees, laboratory technicians, and patient partners for their excellent work and their dedication to advancing scientific knowledge,” said Dr. Michael J. Strong, President, Canadian Institutes of Health Research. “We are proud to support your outstanding research projects that will make a difference in the lives of Canadians.”

CIHR’s largest funding program, the Project Grant competitions support multi-year grants for researchers at various stages in their careers as they conduct research projects that cover the full range of health research topics. The Project Grant program supports “ideas with the greatest potential to advance health-related fundamental or applied knowledge, health research, health care, health systems, and/or health outcomes.”

McGill’s Project Grant recipients are leaders in their fields and their projects tackle pressing health issues that matter to Canadians. These projects range from early prediction of preeclampsia in high-risk pregnancies; and tuberculosis prevention in Nunavik; to identifying predictors of anxiety and depression; and exploring potential therapies for spinal cord injury and stroke.

“We are very grateful for the significant funding from the CIHR to our numerous health-focused research projects at McGill,” said Martha Crago, Vice-Principal, Research and Innovation. “The results of the Project Grant competition highlights McGill’s outstanding contributions and continued leadership in health sciences research. Congratulations to our Fall 2019 cohort who are committed to finding solutions for high-quality health care in Canada.”

Three McGill researchers – Céline Gelinas (Jewish General Hospital); Maziar Divangahi (RI-MUHC); and Giuseppina Ursini-Siegel (Lady Davis Institute); earned two separate Project Grants apiece.

The 16 McGill projects that were awarded CIHR Project Grants include:

  • Dana Anaby, The impact of participation on body functions among youth with physical disabilities: A pragmatic individual-based study, $271,575
  • Neil Andersson, Decolonizing childbirth with Nunavik Inuit women transferred to high-risk hospitals for childbirth: a co-designed pilot intervention, $ 1,718,955
  • Daniel J. Bernard, Novel insights into GnRH regulation of gonadotropin synthesis, $749,700
  • Tyler A. Churchward-Venne, Ketone bodies as therapeutic agents to reduce the harmful effects of bed rest on muscle mass and metabolic health in older adults, $420,750
  • Josée Dostie, Regulating chromatin landscape and organization with non-coding RNAs, $795,600
  • Alyson Elise Fournier, Targeting global programs of gene expression to promote axon regeneration, $1,071,000
  • James L. Gleason, Development of 14-3-3 protein/protein interaction agonists as potential therapies for spinal cord injury and stroke, $286,875
  • David Langlais, IRF1, IRF8 and partners: epigenetic regulators of normal and pathological inflammation, $757,350
  • Alain Nepveu, The Tumor Suppressor Function of CUX1, $673,200
  • Richard D. Roy, AMPK blocks epigenetic misregulation and genome instability following acute starvation in C. elegan, $673,200
  • Reza Salavati, Annotation and discovery of essential pathways in trypanosomatid pathogens, $715,275
  • Thomas Martin Schmeing, Hybrids and commonalities of thiotemplate enzymes, $860,625
  • Alvin Shrier, Quality control and pharmacological rescue of heteromeric long QT mutants, $768,825
  • Faleh Tamimi, Chronotherapy of non-steroidal anti-inflammatory drugs could enhance bone fracture recovery, $558,450
  • Timothy H. Wideman, Improving pain education across entry-level physiotherapy programs in Canada: An integrated knowledge translation study, $604,350
  • Anna Weinberg, Threat and reward sensitivity as markers of stress susceptibility in adolescence: Identifying predictors of anxiety and depression, $581,400

The 19 projects from the Research Institute of the McGill University Health Centre that were awarded CIHR Project Grants include:

  • Faiz Ahmad Khan, Community Health Workers in Tuberculosis Prevention & Care Services in Nunavik, $707,625
  • Carolyn Baglole, Prognostic and Therapeutic Utility of Human Antigen R (HuR) in Fibrosis, $833,850
  • Swneke D. Bailey, Investigating the Molecular Determinants of Peritoneal Metastasis from Gastro-Esophageal Adenocarcinomas, $753,525
  • Nancy E. Braverman, Developing retinal gene augmentation therapy for Zellweger Spectrum Disorder, $933,300
  • Geneviève Bernard, Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies, $1,113,075
  • Pnina Brodt, Regulatory circuits controlling the immune microenvironment of liver metastases, $807,075
  • Samuel David, Ferroptosis-mediated damage in chronic EAE: Implications for progressive MS, $742,050
  • Styliani Daskalopoulou, Early prediction of preeclampsia using arterial stiffness in high-risk pregnancies; a multinational study (PULSE), $1,844,568
  • Maziar Divangahi, Targeting the eicosanoid/macrophage axis to enhance host defense against influenza virus infection, $730,575
  • Maziar Divangahi, Reprogramming HSCs to generate protective trained immunity against TB, $864,450
  • Julio F. Fiore, Jr., Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis, $80,325
  • Jacques Genest, Jr., Familial hypercholesterolemia in Canada: Precision and personalized approaches to increase identification and improve clinical outcomes, $734,400
  • Wassim Kassouf, Implication of neutrophil extracellular traps in the efficacy of bladder-sparing therapy in muscle invasive bladder cancer, $902,700
  • Monzur Murshed, Understanding the mechanism of vascular elastocalcinosis and its prevention by MGP, $925,650
  • Basil J. Petrof, Understanding the basis of diaphragmatic weakness in critical illness, $726,750
  • Giada Sebastiani, The role of fatty liver in the epidemic of advanced chronic liver disease among people living with HIV, $685,440
  • Elena Torban, Actin regulation of ciliogenesis: unraveling novel mechanisms of human ciliopathies caused by mutations in the PCP effector genes, $776,475
  • Ivan V. Litvinov, Ectopic reactivation of normally silenced germ cell programs contributes to genomic instability, carcinogenesis and cancer progression in Cutaneous T-Cell Lymphomas (CTCL), $598,750
  • Simon S. Wing, USP19 in metabolism – mechanisms and translation, $761,175

The seven projects from the Lady Davis Institute for Medical Research that were awarded CIHR Project Grants include:

  • Laurent Azoulay, SGLT-2 inhibitors and early bladder cancer events: An international multi-centre study, $286,875
  • Kristian B. Filion, A personalized dynamic blood pressure control plan for cardiovascular disease prevention among patients with hypertension at low cardiovascular disease risk, $191,250
  • Antonis E. Koromilas, The implication of the adaptive arm of the integrated stress response in KRAS lung cancer, $868,275
  • Tricia Peters, The protective role of physical activity in polycystic ovary syndrome, $105,000
  • Giuseppina Ursini-Siegel, Capitalizing on an oxidative stress response to sensitize poor outcome cancers to PARP inhibitors, $948,600
  • Giuseppina Ursini-Siegel, Understanding how oxidative stress influences tumor evolution via metabolic reprogramming, $975,375
  • Oriana Hoi Yun Yu, Thyroid hormone replacement therapy and the risk of adverse cardiovascular events among individuals with mild subclinical hypothyroidism, $122,400

The three projects from the Douglas Mental Health University Institute that were awarded CIHR Project Grants include:

  • Nicolas Cermakian, Circadian regulation of host-pathogen interactions in vector-borne parasitic infections, $1,005,975
  • Outi Mantere, Growth and empowerment measure adapted for the Indigenous in Quebec – utility evaluation for psychiatric measurement and intervention, $76,500
  • Marie-Josée Fleury, Grands utilisateurs de l’urgence en santé mentale et recommandations pour l’amélioration des services, $371,025

The project from the Montreal Neurological Institute and Hospital that was awarded a CIHR Project Grant:

  • Thomas M. Durcan, Unravelling the complex process of synuclein seeding and propagation with human stem cell derived models, $726,750

The five projects from the Jewish General Hospital that were awarded CIHR Project Grants include:

  • Jonathan Afilalo, Geriatric intervention for frail heart failure patients: The GIF-HF trial, $428,400
  • Mark J. Eisenberg, Youth and e-cigarettes: A knowledge synthesis, $114,750
  • Céline Gelinas, Managing Pain in Collaboration in the Intensive Care Unit (MPIC-ICU): Impact on clinical practices and patient outcomes, $684,675
  • Céline Gelinas, Validation of a new multi-parameter technology to better diagnose pain in the adult intensive care population: The Nociception Level (NOL) Index, $524,025
  • Alexander Thiel, Non-invasive PET imaging of tropomyosin related kinase B/C receptor in humans, $579,105

 

 

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